What is specific antibody deficiency?
Individuals with specific antibody deficiency have normal levels of antibodies (immunoglobulins) but cannot produce antibodies to specific types of microorganisms that cause respiratory infections.
What are the causes of antibody deficiencies?
Although the exact cause of specific antibody deficiency is not known, it is likely due to a genetic mutation.
What are the symptoms of antibody deficiencies?
Some patients do not present with symptoms of antibody deficiencies because other components of their immune system are still functional. Some patients show an increase frequency of infections in the first few years of life. For others, the onset of infections may not occur until adulthood. Symptoms may include recurrent infections of the ears, sinuses, lungs, or skin. If left untreated, this can lead to severe illness and hospitalization.
How are specific antibody deficiencies diagnosed?
Specific antibody deficiencies may be considered by an immunologist in children or adults who have a history of recurrent infections. Evaluation typically includes blood tests to measure the total amount of immunoglobulins and antibody levels to specific bacteria or vaccines.
How are specific antibody deficiencies treated?
The most common treatments for immunodeficiencies include preventing and treating infections and boosting the immune system:
- Treating infections – some infections require rapid and aggressive treatment with antibiotics. This may require a longer course than prescribed depending on the infection.
- Preventing infections – long-term antibiotics can be a strategy to prevent respiratory infections and permanent damage to the lungs and ears.
- Immunoglobulin therapy – Immunoglobulin replacement therapy contains proteins that your immune system uses to fight infections (immunoglobulins and antibodies). Replenishing these back to a normal level can help prevent further infections. Immunoglobulin replacement can be done in the vein (IV) or under the skin (subcutaneous).
