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Calcium Pyrophosphate Deposition

 

What is CPPD disease?

Calcium pyrophosphate deposition, also known as pseudogout, is a specific form of arthritis. This form of arthritis is when crystals start to form in the blood. These crystal deposits then start to live in your joints and can cause severe joint inflammation and discomfort. 

What causes CPPD?

While we know that CPPD is caused by the crystal deposits, the cause of the formation of the crystal deposits is still unknown. While there is a not an answer for this, we do know that people with any of the following may have an increased risk of also having pseudogout:

  • Calcium disorders
  • Insufficient magnesium levels
  • Kidney failure
  • Thyroid disorder
  • Osteoarthritis
  • Gout

Pseudogout Symptoms

The symptoms of pseudogout stay consistent with the list below. These symptoms are most frequently seen in the knees but can also be found in other joints.

  • Swollen joints
  • Joints that are tender or warm to the touch
  • Strong joint pain
  • Reddening skin around the affected joint

Diagnosing Pseudogout

The diagnosis process for you will be based on your health history as well as the current symptoms you are experiencing. The diagnosis process will likely start with a blood test. To get a better view of the calcium crystals, imaging tests may be ordered such as an MRI, X-ray or CT scan. Finally, fluid may be withdrawn out of the affected joint and sent in for testing.

Pseudogout Treatment

The treatment options that are presented to you will be based on the severity of your symptoms as well as how often you are experiencing flare ups. One of the most common pseudogout treatment options is anti-inflammatory drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs). If you’re unable to take NSAIDs you may be prescribed corticosteroids. Prior to getting a corticosteroid, your rheumatologist may drain any excess fluid from the joint. For severely damaged joints, joint replacement surgery may be recommended.

If you have any questions regarding pseudogout, contact the Iowa Clinic Rheumatology department at 515.875.9790.