What is BARD1 gene mutation?
BARD1 (BRCA1-associated RING Domain 1) is a gene that works in conjunction with the BRCA1 gene to repair damaged DNA and prevent the development of cancer. Mutations in the BARD1 gene can impair its function, leading to an increased risk of developing certain cancers, including breast cancer.
What are the risks associated with BARD1 gene mutation?
Individuals with a BARD1 gene mutation have an increased risk of developing breast cancer, although the magnitude of the risk is not as well defined as with BRCA1 and BRCA2 mutations. Research suggests that BARD1 mutations may be associated with a moderate increase in breast cancer risk, particularly in families with a history of the disease.
How do I determine if I have BARD1 gene mutation?
If you have a family history of breast cancer or other risk factors suggestive of a BARD1 gene mutation, we recommend scheduling a consultation with your healthcare provider. During your consultation, the following may be recommended:
- Genetic Counseling and Testing: Genetic counseling and testing for BARD1 gene mutations to identify inherited genetic alterations associated with an increased risk of breast cancer.
- Personalized Screening: Personalized screening recommendations based on your genetic test results, family history, and individual risk factors. Screening may include breast imaging studies such as mammography, breast MRI, or breast ultrasound for early detection and surveillance.
- Risk-Reducing Strategies: Risk-reducing strategies such as increased surveillance, chemoprevention (medications to reduce cancer risk), or risk-reducing surgery (mastectomy or oophorectomy) may be considered for individuals with BARD1 mutations, depending on their individual risk profile.