Genetic Testing for Breast Cancer
Genetic testing for breast cancer risk involves examining an individual's DNA to identify changes or mutations that could cause diseases or conditions.
There are many genes associated with breast cancer and other types of cancer as well. One mutation can increase your risk of breast, ovarian, colon or other cancers — it just depends on the gene. By identifying if you’re at an elevated risk of developing a malignancy, we can offer more aggressive surveillance and, hopefully, pick up any changes when they are small, early and most treatable.
While only 15 percent of breast cancers are associated with gene mutations, genetic testing can identify whether you have one of the known mutations. From there, you can take a more proactive approach to monitoring your breast health.
Am I at high risk for breast cancer?
Individuals may be considered high-risk for breast cancer if they have one or more of the following risk factors:
- Family History: A personal or family history of breast cancer, particularly at a young age or in multiple relatives, may suggest an increased risk.
- Genetic Mutations: Inherited mutations in certain genes, such as BRCA1, BRCA2, CHEK2, BARD1, and others, significantly increase the risk of breast cancer.
- Personal History: A personal history of certain benign breast conditions, such as lobular carcinoma in situ (LCIS) or atypical hyperplasia, may increase the risk of developing breast cancer.
- Radiation Exposure: Previous radiation therapy to the chest area, particularly during childhood or adolescence, may increase the risk of breast cancer.
- Hormonal Factors: Hormonal influences, such as early menstruation, late menopause, hormone replacement therapy, and oral contraceptive use, may affect breast cancer risk.
Breast Cancer Evaluation and Screening Recommendations
If you are concerned about your risk of breast cancer or have a family history of the disease, we recommend scheduling a consultation with your healthcare provider. During your consultation, you will go through a thorough evaluation, which may include:
- Personal and Family History: We will review your personal and family medical history to assess your risk factors for breast cancer.
- Genetic Counseling and Testing: Genetic counseling and testing may be recommended for individuals with a family history of breast cancer or other risk factors suggestive of an inherited genetic mutation. Genetic testing can identify inherited mutations in genes associated with breast cancer risk, such as BRCA1 and BRCA2.
- Breast Imaging: Depending on your age, risk factors, and personal history, we may recommend breast imaging studies such as mammography, breast MRI, or breast ultrasound for early detection and surveillance.
- Risk Assessment Tools: Risk assessment tools such as the Gail Model, Tyrer-Cuzick Model, or Breast Cancer Risk Assessment Tool (BCRAT) may be used to estimate an individual's lifetime risk of developing breast cancer based on various risk factors.
Expert Care for Genetic Predisposition to Breast Cancer at The Iowa Clinic
At The Iowa Clinic, we understand the concerns and uncertainties associated with genetic predisposition to breast cancer. Our compassionate team of healthcare professionals is dedicated to providing you with expert evaluation, accurate genetic testing, personalized screening recommendations, and comprehensive care options tailored to your unique needs. Contact us today to schedule a consultation and take proactive steps towards managing your breast health and reducing your risk of breast cancer.